Andractim 80g (Dihydrotestosterone Topical Gel) is the first new drug for treating congenital micropenis.
【Packaging Specifications】: 80g/tube, topical gel
【Manufacturer】: Besins International, France
【Trade Name】: Andractim DHT 2.5% Gel
【Drug Name】: Dihydrotestosterone Gel
【Chinese Alias】: 17β-hydroxy-5α-androstane-3-one
【Indications for Andractim Dihydrotestosterone】
1. Treatment of gynecomastia, micropenis, hypogonadism, reduced catabolism (e.g., weight loss due to AIDS), lichen sclerosus in women, and male contraception.
2. Testosterone gel is an androgen used for replacement therapy in adult men with endogenous testosterone deficiency or related conditions:
● Primary hypogonadism (congenital or acquired) – cryptorchidism, bilateral torsion, orchitis, orchiectomy syndrome, testicular failure due to orchiectomy. ● Klinefelter syndrome, chemotherapy, alcohol or heavy metal poisoning. These men typically have low serum testosterone levels and elevated gonadotropin (FSH, LH) levels.
● Hypogonadotropinemia (congenital or acquired) – idiopathic gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic damage caused by tumors, trauma, or radiation therapy. These men have low serum testosterone levels, but gonadotropin levels are within the normal or lower range.
【Contraindications for Andractim Dihydrotestosterone】
1. Testosterone gel is contraindicated in men with breast cancer or known or suspected prostate cancer.
2. Testosterone gel is contraindicated in women who are pregnant or may become pregnant, or who are breastfeeding. Use of testosterone gel in pregnant women may harm the fetus.
Testosterone gel may cause serious adverse reactions in nursing infants. Exposure of the fetus or a urinating infant to androgens may lead to varying degrees of masculinization. Potentially pregnant women or those using testosterone gel should be aware of the potential for testosterone transfer in men treated with testosterone gel. If a pregnant woman is exposed to testosterone gel, she should be informed of the potential harm to the fetus.
【Andractim Dihydrotestosterone Drug Interactions】
1. Insulin
Patients treated with androgens may experience changes in insulin sensitivity or glycemic control. In diabetic patients, the metabolic effects of androgens may affect glycemia, thus affecting insulin requirements.
2. Oral Anticoagulants
Androgens can cause changes in anticoagulant activity. More frequent monitoring of INR and prothrombin time is recommended in patients taking anticoagulants, especially at the start and end of androgen therapy.
3. Glucocorticoids
Concomitant use of testosterone with adrenocorticotropic hormone (ACTH) or corticosteroids may lead to increased fluid retention and should be carefully monitored, especially in patients with heart, kidney, or liver disease.
【Andractim (Dihydrotestosterone) Usage and Dosage】
Andractim 2.5% Gel: For topical application, once daily (Children: noticeable effects in 15 days; Adults: noticeable effects in 25 days).
Generally, 12 tubes are sufficient!
1 tube: Enough for 16 days
2 tubes: Enough for 32 days
4 tubes: Enough for 64 days
【Andractim (Dihydrotestosterone) Usage Instructions】
Andractim 2.5% gel is for external use only. Apply to the desired skin area after washing. Allow the gel to dry for approximately five minutes before dressing.
Put on gloves.
Gently squeeze the gel onto the mark shown on the lamination information sheet – follow the instructions on the dispensing label.
Distribute evenly over the desired area.
Leave for five minutes.
Wipe the lamination information sheet with a damp paper towel to prepare for the next dose. Remove gloves and wash with warm soapy water to prepare for the next dose.
Note: Dihydrotestosterone 2.5% gel should not be applied to any broken skin.
Dihydrotestosterone is a synthetic form of a hormone called testosterone. It is used for children with hormone deficiency. This information sheet from Great Ormond Street Hospital (GOSH) explains the concentration of the 2.5% gel, how to use it, and some possible side effects.
Andractim 80g（双氢睾酮外用凝胶）为首款治疗先天阴茎短小新药。
【包装规格】：80克/支，外用凝胶
【生产厂家】:法国Besins International
【商品名】:Andractim DHT 2.5% Gel
【药品名】:Dihydrotestosterone（双氢睾酮凝胶）
【中文别名】: 17β-羟基-5α-雄甾烷-3-酮
【Andractim双氢睾酮适应症】
1.治疗男子女性乳房发育、小阴茎、性腺功能减退、降低分解代谢，例如艾滋病引起的消瘦、女性硬化萎缩性苔藓，以及男性避孕。
2.睾酮凝胶是一种雄激素，用于成年男性内源性睾酮缺乏或缺乏相关情况的替代治疗:
● 原发性性腺功能减退(先天性或后天)-隐睾、双侧扭转、睾丸炎、睾丸消失综合征、睾丸切除术引起的睾丸功能衰竭。克兰费尔特综合症，化疗，酒精或重金属中毒。这些男性通常血清睾酮水平较低，促性腺激素(FSH, LH)高于正常范围。
● 促性腺功能减退症(先天性或获得性)-特发性促性腺激素或促黄体生成素释放激素(LHRH)不足或肿瘤、外伤或放疗引起的垂体-下丘脑损伤。这些男性血清睾酮水平较低，但促性腺激素水平在正常或较低范围。
【Andractim双氢睾酮禁忌症】
1.男性乳腺癌或已知或疑似前列腺癌患者禁用睾酮凝胶。
2.睾酮凝胶是禁忌的妇女谁或可能怀孕，或谁是母乳喂养。当给孕妇使用睾丸素凝胶时，可能会对胎儿造成伤害。
睾酮凝胶在哺乳婴儿中可能引起严重的不良反应。胎儿或正在排尿的婴儿暴露于雄激素可能导致不同程度的男性化。可能怀孕的孕妇或软管需要意识到使用睾酮凝胶治疗的男性的睾酮转移的潜力。如果孕妇接触睾酮凝胶，应告知其对胎儿的潜在危害。
【Andractim双氢睾酮药物相互作用】
1.胰岛素
用雄激素治疗的患者可能会发生胰岛素敏感性或血糖控制的变化。在糖尿病患者中，雄激素的代谢影响可能影响血糖，因此影响胰岛素的需求。
2.口服抗凝血剂
雄激素可以引起抗凝血活性的变化。建议在服用抗凝剂的患者中更频繁地监测INR和凝血酶原时间，特别是在雄激素治疗的开始和结束时。
3.糖皮质激素
在睾酮与促肾上腺皮质激素或皮质类固醇同时使用可能导致液体潴留增加，应谨慎监测，特别是对有心脏、肾脏或肝脏疾病的患者。
【Andractim双氢睾酮用法与用量】
双氢睾酮（Andractim）2.5％凝胶：局部应用，每日一次（儿童：使用15天即可以见效，成年：25天可见效）.
一般用12管即可！
1管：足够用16天
2管：足够用32天
4管：足够用64天
【Andractim双氢睾酮使用方法】
双氢睾酮2.5％凝胶仅供外用。应该在洗涤后涂抹在所需的皮肤区域。在穿上衣服之前，应将凝胶保持干燥五分钟左右。
戴上一副手套
轻轻地将凝胶挤压到层压信息表上所示标尺上的标记处-按照点胶标签上的说明进行操作。
均匀分布在所需区域
离开五分钟
用湿纸片擦拭层压信息表，准备下一次剂量。取下手套，用温肥皂水清洗，准备下一剂。
注意：双氢睾酮2.5％凝胶不应涂在任何破损的皮肤区域。
双氢睾酮是一种称为睾酮的激素的合成形式。用于有激素缺乏症的儿童。 来自Great Ormond Street Hospital（GOSH）的这份信息表解释了2.5％凝胶的含量，使用方法以及一些可能的副作用。
| Choose a special offer package | One bottle: S$160, Two bottles: S$310, Four bottles: S$600 |
|---|
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